Epigenetics
Biological Age
Diagnostics
Supplements
DNA Methylation
GLP-1 Agonists
Cellular Aging
Every longevity intervention scored against human randomised controlled trial data. Clear verdicts. No animal studies. No affiliates. No noise.
Epigenetics
Biological Age
Diagnostics
Supplements
DNA Methylation
GLP-1 Agonists
Cellular Aging
Scored against human RCT data only. Instant PDF download.
The same person tested twice in 30 days can swing 5–10 years. GrimAge, DunedinPACE, Horvath, GlycanAge — all scored. Find out what you are actually measuring before spending $600 per test.
20 interventions scored. NMN, Resveratrol, Berberine, Fisetin, AKG, Rapamycin and more. Find out what your stack is actually worth — and what to cut immediately.
The SELECT trial showed 19% reduction in all-cause mortality. Not weight loss — mortality. The cardiovascular, cognitive, and lifespan data beyond the headlines, scored honestly.
Less than 6 hours per night: 12% increased all-cause mortality. Most melatonin users are overdosing 10–20x. CBT-I outperforms sleeping pills. The evidence-ranked protocol.
50+ interventions. One master scorecard. Fill-in personal audit worksheet — list every supplement you take, find its grade, total your monthly waste on AVOID-rated products. If you are spending over $100/month on supplements this report will almost certainly find money to cut immediately.
Each report is self-contained. Together they cover every major longevity decision — diagnostics, supplements, metabolic drugs, sleep, and your full personal protocol.
The same rubric applied to every supplement, diagnostic, drug, and protocol. No exceptions.
Animal studies are excluded from scoring. Mechanistic plausibility is excluded. Only replicated human randomised controlled trials count as evidence.
Every intervention is scored on: RCT count, effect size, replication quality, risk profile, and consumer usefulness. Identical rubric for every category.
Start — strong evidence supports use. Stop — evidence contradicts use. Wait — promising but incomplete. Ignore — insufficient evidence to act on.
A sample from our published reports. Full breakdown and methodology inside each report.
| Intervention | Category | Verdict | Evidence Note |
|---|---|---|---|
| GrimAge Clock | Epigenetic Tests | WAIT | Strongest mortality predictor. One baseline test reasonable. Quarterly testing is not. |
| Resveratrol | Polyphenols | AVOID | Multiple human RCTs largely negative. Does not confirm animal data in humans. |
| Berberine | Metabolic | START | 40+ human RCTs. Glucose reduction comparable to metformin in some studies. |
| Semaglutide (CV outcomes) | GLP-1 Agonists | START — if eligible | SELECT trial: 20% MACE reduction, 19% all-cause mortality reduction. 17,604 participants. |
| High-dose Melatonin (5–10mg) | Sleep | AVOID | 10–20x physiological dose. Disrupts circadian rhythm. Most people overdosing significantly. |
| Magnesium Glycinate | Foundational | START | 100+ human RCTs. Most adults deficient. Sleep, cardiovascular, metabolic benefits documented. |
| Quarterly Epigenetic Testing | Diagnostics | AVOID | Test-retest variance too high. Measuring noise not biology. Costs $1,200–$2,400/year. |
| Rapamycin | mTOR Inhibition | WAIT | Most compelling longevity drug in animal models. Healthy human adult data thin. PEARL trial ongoing. |
| Full evidence breakdown in each report → Browse Reports | |||
Zero revenue from supplement companies, diagnostic labs, or drug manufacturers. A product cannot buy a better verdict from Life130.
Animal studies are excluded from our evidence rubric. A molecule that extends mouse lifespan and fails in human trials is scored on the human data.
Popular interventions fail our rubric when the evidence does not support them. Unpopular interventions pass when the evidence does.
Every report states its evidence cutoff date. When major new trials publish, verdicts are updated. No stale reports presented as current.
The reproducibility data alone was worth the $39. I had no idea the same test could swing 8 years in 30 days. I cancelled my quarterly testing protocol immediately.
Finally someone scored these tests against actual human trials instead of repeating what the companies say. The GlycanAge finding surprised me — I had been using it as an aging clock for two years.
The Start / Stop / Wait / Avoid framework is exactly what was missing from every other longevity review I have read. Concrete. Actionable. No hedging.
Every report gives you a clear verdict on every intervention — scored against human trial data. From $27. Instant download.
Instant PDF download · No subscription · No personal data sold · No affiliates